Current Genomics

Christian Néri
Institute of Biology Paris-Seine
CNRS UMR 8256 and UPMC
Paris, 75005


Systems Biology Experimental Design - Considerations for Building Predictive Gene Regulatory Network Models for Prokaryotic Systems

Author(s): Marc T. Facciotti, Richard Bonneau, Leroy Hood and Nitin S. Baliga

Affiliation: Institute for Systems Biology, 1441 N. 34th St., Seattle, WA, 98103, USA.

Keywords: systems biology, experimental design, prokaryotic, quantitative


The goal of systems biology is to describe and quantitatively model complete biological systems. It is a reasonable goal to begin by developing quantitative models that accurately recapitulate many aspects of gene regulatory networks for some simple organisms. We consider here the advantages of using prokaryotic organisms as model systems in the initial development of such quantitative models. In addition, we discuss some of the benefits of studying stress responses in these organisms and illustrate some of the biological and theoretical complexities facing the analyses of dynamic biological systems.

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Article Details

Page: [527 - 544]
Pages: 18
DOI: 10.2174/1389202043348850