General Principles of Photodynamic Therapy (PDT) and Gastrointestinal Applications

Author(s): Marcus W. Wiedmann, Karel Caca.

Journal Name: Current Pharmaceutical Biotechnology

Volume 5 , Issue 4 , 2004

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Abstract:

The purpose of this review article is to describe the history of photodynamic therapy (PDT), its current medical applications, the mechanism of action, contraindications of the method, and different types of photosensitizers used. The second part of the article deals with applications for gastrointestinal diseases. The treatment of obstructing oesophageal cancer, early-stage oesophageal cancer, Barretts esophagus, hilar cholangiocarcinoma, stomach-, colon- and pancreatic cancer are discussed. The final part focuses on future directions of PDT like certain innovative ideas, which are currently under investigation.

Keywords: photodynamic therapy, photosensitizers, gastrointestinal diseases, oesophageal cancer, pancreatic cancer

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Article Details

VOLUME: 5
ISSUE: 4
Year: 2004
Page: [397 - 408]
Pages: 12
DOI: 10.2174/1389201043376805
Price: $58

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