Deoxyribozymes as Inhibitors of Vascular Smooth Muscle Cell Growth

Author(s): Levon M. Khachigian.

Journal Name: Current Pharmaceutical Biotechnology

Volume 5 , Issue 4 , 2004

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Abstract:

DNA enzymes, or DNAzymes, are all-DNA molecules with inherent catalytic activity that bind and cleave at their complementary sequence in the target mRNA through Watson-Crick base pairing. These agents have been successfully used to tease out the role the targeted gene plays in both cellular systems and in a variety of animal models. DNAzymes have the potential to serve as novel nucleic acid-based therapeutic agents in pathologies involving aberrant smooth muscle cell growth and a range of other disorders.

Keywords: dnazymes, post-angioplasty restenosis, egr-1

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Article Details

VOLUME: 5
ISSUE: 4
Year: 2004
Page: [337 - 339]
Pages: 3
DOI: 10.2174/1389201043376788
Price: $58

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