Abstract
Extensive attempts to overcome problems related to solubility of drugs for maximizing bioavailability at targeted sites in the body have been made. The issue of drug solubility appears to attract the continued interest of pharmaceutical manufacturers. In this context, nanocrystallization has emerged as an important tool. In the present review, the authors discuss the advantages of nanocrystallized drugs and examine the products available in the market as well as drugs in the pipeline using nanocrystal-based formulations, which are being developed by pharmaceutical companies for drug delivery.
Keywords: Nanocrystal, drug delivery, drugs, nanocrystallization, Poorly Soluble Drugs, pharmacological screenings, micronization, bioavailability, Dissolution Velocity, toxic chemicals
Current Drug Delivery
Title: Nanocrystal Technology in the Delivery of Poorly Soluble Drugs: An Overview
Volume: 8 Issue: 4
Author(s): Ramesh C. Nagarwal, Rakesh Kumar, Meenakshi Dhanawat, Nirupam Das and J. K. Pandit
Affiliation:
Keywords: Nanocrystal, drug delivery, drugs, nanocrystallization, Poorly Soluble Drugs, pharmacological screenings, micronization, bioavailability, Dissolution Velocity, toxic chemicals
Abstract: Extensive attempts to overcome problems related to solubility of drugs for maximizing bioavailability at targeted sites in the body have been made. The issue of drug solubility appears to attract the continued interest of pharmaceutical manufacturers. In this context, nanocrystallization has emerged as an important tool. In the present review, the authors discuss the advantages of nanocrystallized drugs and examine the products available in the market as well as drugs in the pipeline using nanocrystal-based formulations, which are being developed by pharmaceutical companies for drug delivery.
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Cite this article as:
C. Nagarwal Ramesh, Kumar Rakesh, Dhanawat Meenakshi, Das Nirupam and K. Pandit J., Nanocrystal Technology in the Delivery of Poorly Soluble Drugs: An Overview, Current Drug Delivery 2011; 8 (4) . https://dx.doi.org/10.2174/156720111795767988
DOI https://dx.doi.org/10.2174/156720111795767988 |
Print ISSN 1567-2018 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5704 |
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