Abstract
Papillary carcinoma of the thyroid is a common malignancy originating from the endocrine organs. The recent prevalence of ultrasonography (US) and US-guided fine needle aspiration biopsy (FNAB) can make us easily diagnose papillary carcinoma of 1.0 cm or less in maximal diameter, which is called papillary microcarcinoma. How to treat papillary microcarcinoma has been controversial. In autopsy studies, papillary carcinoma of 3-9.9 mm is frequently found as an occult carcinoma. Furthermore, papillary carcinoma of more than 3 mm was detected in 3.5% of otherwise healthy women aged 30 years or older by mass screening using US and FNAB, and 84% of them were less than 1.5 cm in diameter. These findings indicate that papillary microcarcinoma frequently remains occult. Thus, recently, a trial of observation without surgical treatment has been performed, which demonstrates that most papillary microcarcinoma do not grow or only slowly grow and observation can be a therapeutic strategy. On the other hand, previous reports demonstrated that papillary microcarcinoma frequently metastasizes to cervical lymph nodes and shows multiple tumor formation in the thyroid. Furthermore, cases with palpable nodal metastasis often show rapid progression and dire prognosis. In this review, we discuss the appropriate application of observation and surgical treatment of papillary microcarcinoma.
Keywords: thyroid cancer, microcarcinoma, surgery, observation
Current Cancer Therapy Reviews
Title: Therapeutic Strategies for Papillary Microcarcinoma of the Thyroid
Volume: 1 Issue: 1
Author(s): Yasuhiro Ito and Akira Miyauchi
Affiliation:
Keywords: thyroid cancer, microcarcinoma, surgery, observation
Abstract: Papillary carcinoma of the thyroid is a common malignancy originating from the endocrine organs. The recent prevalence of ultrasonography (US) and US-guided fine needle aspiration biopsy (FNAB) can make us easily diagnose papillary carcinoma of 1.0 cm or less in maximal diameter, which is called papillary microcarcinoma. How to treat papillary microcarcinoma has been controversial. In autopsy studies, papillary carcinoma of 3-9.9 mm is frequently found as an occult carcinoma. Furthermore, papillary carcinoma of more than 3 mm was detected in 3.5% of otherwise healthy women aged 30 years or older by mass screening using US and FNAB, and 84% of them were less than 1.5 cm in diameter. These findings indicate that papillary microcarcinoma frequently remains occult. Thus, recently, a trial of observation without surgical treatment has been performed, which demonstrates that most papillary microcarcinoma do not grow or only slowly grow and observation can be a therapeutic strategy. On the other hand, previous reports demonstrated that papillary microcarcinoma frequently metastasizes to cervical lymph nodes and shows multiple tumor formation in the thyroid. Furthermore, cases with palpable nodal metastasis often show rapid progression and dire prognosis. In this review, we discuss the appropriate application of observation and surgical treatment of papillary microcarcinoma.
Export Options
About this article
Cite this article as:
Ito Yasuhiro and Miyauchi Akira, Therapeutic Strategies for Papillary Microcarcinoma of the Thyroid, Current Cancer Therapy Reviews 2005; 1 (1) . https://dx.doi.org/10.2174/1573394052952546
DOI https://dx.doi.org/10.2174/1573394052952546 |
Print ISSN 1573-3947 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6301 |
Call for Papers in Thematic Issues
Current progress in Protein Degradation and Cancer Therapy
argeted Protein Degradation is gaining momentum in cancer therapy, it facilitate targeting undruggable proteins, it overcome cancer resistance and avoid undesirable side effects. Thus small molecules degraders have emerged as novel therapeutic strategy. Targeted protein degradation (TPD), the process of eliminating a protein of interest hold a great promise for ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Mitochondrial Biogenesis in Health and Disease. Molecular and Therapeutic Approaches
Current Pharmaceutical Design Tumour Re-Differentiation Effect of Retinoic Acid: A Novel Therapeutic Approach for Advanced Thyroid Cancer
Current Pharmaceutical Design Machine Learning Techniques and Drug Design
Current Medicinal Chemistry Cancer Immunotherapy - Immune Checkpoint Inhibitors in Hepatocellular Carcinoma
Recent Patents on Anti-Cancer Drug Discovery Nongenomic Actions of Thyroid Hormones: From Basic Research to Clinical Applications. An Update
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) Monoamine Oxidases: Certainties and Uncertainties
Current Medicinal Chemistry Early Intervention in Psychosis: Rationale, Results and Implications for Treatment of Adolescents at Risk
Adolescent Psychiatry Targeting Histone Deacetylases for the Treatment of Immune, Endocrine & Metabolic Disorders
Endocrine, Metabolic & Immune Disorders - Drug Targets Delta Np63 alpha – Responsive microRNA Modulate the Expression of Metabolic Enzymes
Current Pharmaceutical Biotechnology Epigenetic Modulators as Treatment Alternative to Diverse Types of Cancer
Current Medicinal Chemistry ABC Subfamily D Proteins and Very Long Chain Fatty Acid Metabolism as Novel Targets in Adrenoleukodystrophy
Current Drug Targets Thyroid Hormone Treatment for Differentiated Thyroid Carcinoma: What Drug, How Long, What Dose?
Current Cancer Therapy Reviews Novel Therapeutic Strategies for Fibrotic Lung Disease: A Review with a Focus on Epithelial-Mesenchymal Transition
Recent Patents on Inflammation & Allergy Drug Discovery The Role of the Calcium-Sensing Receptor in Human Pathophysiology
Current Medicinal Chemistry - Immunology, Endocrine & Metabolic Agents Immunomodulatory Activities of Glucocorticoids: Insights from Transgenesis and Gene Targeting
Current Pharmaceutical Design Circadian Cycle and Chronotherapeutics: Recent Trend for the Treatment of Various Biological Disorders
Recent Patents on Drug Delivery & Formulation Di / tri-Peptide Transporters as Drug Delivery Targets: Regulation of Transport Under Physiological and Patho-physiological Conditions
Current Drug Targets Gadd45 Proteins as Critical Signal Transducers Linking NF-κB to MAPK Cascades
Current Cancer Drug Targets Mitochondrial Uncoupling and the Regulation of Glucose Homeostasis
Current Diabetes Reviews MicroRNAs in the Intracellular Space, Regulation of Organelle Specific Pathways in Health and Disease
MicroRNA