Screening for Protease Substrate by Polyvalent Phage Display

Author(s): Radislav Sedlacek, Emily Chen.

Journal Name: Combinatorial Chemistry & High Throughput Screening
Accelerated Technologies for Biotechnology, Bioassays, Medicinal Chemistry and Natural Products Research

Volume 8 , Issue 2 , 2005

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Abstract:

Proteases are key regulators of many physiological and pathological processes [1,2], and are recognized as important and tractable drug candidates. Consequently, knowledge of protease substrate recognition and specificity promotes identification of biologically relevant substrates, helps elucidating a

Keywords: phage display, matrix metalloproteinases, substrate profiling

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Article Details

VOLUME: 8
ISSUE: 2
Year: 2005
Page: [197 - 203]
Pages: 7
DOI: 10.2174/1386207053258541
Price: $65

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