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Combinatorial Chemistry & High Throughput Screening

Editor-in-Chief

ISSN (Print): 1386-2073
ISSN (Online): 1875-5402

Combinatorial Chemistry in Glycobiology

Author(s): Obadiah J. Plante

Volume 8, Issue 2, 2005

Page: [153 - 159] Pages: 7

DOI: 10.2174/1386207053258523

Price: $65

Abstract

The application of combinatorial chemistry to glycobiology historically has proven challenging due to numerous synthetic hurdles. The advent of novel methodologies has enabled the production of natural as well as mimetic analogues for proof-of-concept experiments and SAR. This review highlights some of the recent synthetic advances in combinatorial carbohydrate synthesis. The application of carbohydrate libraries in glycobiology is also discussed.

Keywords: drug discovery, high-throughput assays, glycobiology, deprotection-coupling cycles, stereoselectivity, gram-negative bacteria


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