Synthetic Peptide Arrays and Peptide Combinatorial Libraries for the Exploration of Protein-Ligand Interactions and the Design of Protein Inhibitors

Author(s): Jutta Eichler.

Journal Name: Combinatorial Chemistry & High Throughput Screening
Accelerated Technologies for Biotechnology, Bioassays, Medicinal Chemistry and Natural Products Research

Volume 8 , Issue 2 , 2005

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Abstract:

Synthetic peptides have a long tradition as molecular tools in biomedical research and drug discovery. The introduction of high-throughput synthesis and screening technologies for synthetic peptides, such as arrays and combinatorial libraries, enabled the large-scale and detailed exploration of protein-ligand interactions, as well as the discovery of novel biologically active peptides. This review summarizes currently available synthetic peptide array and library technologies, in particular mixture-based peptide libraries, which are illustrated by numerous applications in various fields of biomedical research.

Keywords: protein-ligand interactions, protein chips, two-dimensional arrays, synthetic peptide combinatorial libraries, surface plasmon resonance, infectious diseases, signal transduction kinase, phosphotransferase system

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Article Details

VOLUME: 8
ISSUE: 2
Year: 2005
Page: [135 - 143]
Pages: 9
DOI: 10.2174/1386207053258497
Price: $65

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