Novel Targets for Cardiac Antiarrhythmic Drug Development

Author(s): John Christian Hesketh, Daniel Herrera, Stephen Zicha, Stanley Nattel.

Journal Name: Current Pharmaceutical Design

Volume 11 , Issue 15 , 2005

Abstract:

Cardiac arrhythmias remain a major source of morbidity and mortality in developed countries. Antiarrhythmic drug therapy was traditionally the mainstay of cardiac arrhythmia treatment; however, drug therapy of cardiac arrhythmias has been plagued by incomplete efficacy and by potentially serious adverse reactions, of which the most worrisome has been a potential for malignant proarrhythmia and related effects to increase cardiac mortality. This article reviews the principal arrhythmia mechanisms and their ionic determinants, and discusses potential innovative approaches to new antiarrhythmic drug development, including the consideration of novel ionic targets, potential biophysical approaches and non-channel components involved in composing the arrhythmic substrate.

Keywords: sinoatrial node (san), pacemaker, re-excitation, early afterdepolarizations(eads), sarcoplasmic reticulum (sr), automaticity, sodium current, channels, ultra rapid delayed rectifier, antiarrhythmic therapy

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Article Details

VOLUME: 11
ISSUE: 15
Year: 2005
Page: [1959 - 1974]
Pages: 16
DOI: 10.2174/1381612054021051
Price: $58