Branched Selective Hydroformylation: A Useful Tool for Organic Synthesis

Author(s): Matthew L. Clarke .

Journal Name: Current Organic Chemistry

Volume 9 , Issue 7 , 2005

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Abstract:

Hydroformylation reactions that show branched regioselectivity are reviewed. The mechanism of hydroformylation and the current state of the art in linear selective hydroformylation is briefly discussed prior to a more in depth discussion on synthetically useful branched selective hydroformylation reactions. The review divides these into several different classes; hydroformylation of internal cyclic alkenes, acyclic internal alkenes, aryl alkenes, terminal alkenes bearing electron withdrawing groups, terminal alkenes bearing groups that can potentially co-ordinate to the rhodium catalysts, and simple terminal alkenes. Recent advances in asymmetric hydroformylation are also discussed. The review aims to provide the non-specialist and expert reader with the information required to assess the type of substrate, catalyst and reaction conditions that are likely to be conducive to obtaining branched aldehydes in a hydroformylation reaction.

Keywords: alkenes, polymers, rh catalysed hydroformylation, phosphabarrelene, palladium catalysed coupling

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Article Details

VOLUME: 9
ISSUE: 7
Year: 2005
Page: [701 - 718]
Pages: 18
DOI: 10.2174/1385272053764980
Price: $58

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