Current Drug Delivery

Istvan Toth
School of Pharmacy,University of Queensland
Brisbane, 4072
Australia

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Lipid-Protamine-DNA-Mediated Antigen Delivery

Author(s): Dileep P. Vangasseri, Su-Ji Han, Leaf Huang.

Abstract:

The development of novel new generation vaccine systems that is based on proteins, peptides or DNA is of great current interest. However, due to the lower efficiencies of these new generation vaccines, they are seldomly used alone. Rather, their formulations often contain adjuvants, either to enhance the immune responses or to reduce dosing. The present chapter will provide a brief overview of the recent advances in peptide-based cancer vaccine adjuvants, focusing mainly on Liposome-Protamine-DNA (LPD) nanoparticle-mediated antigen delivery.

Keywords: immunogens, cancer vaccines, peptide antigen, mhc molecule, antigen presenting cells (apc), anti-tumor

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Article Details

VOLUME: 2
ISSUE: 4
Year: 2005
Page: [401 - 406]
Pages: 6
DOI: 10.2174/156720105774370168
Price: $58