Of Man in Mouse: Modelling Human Cancer Genotype-Phenotype Correlations in Mice

Author(s): Maria Perez-Caro, Pedro A. Perez-Mancera, Felipe Voces, Isidro Sanchez-Garcia.

Journal Name: Current Genomics

Volume 6 , Issue 2 , 2005

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Abstract:

To date, many genetic changes have been described and reported in the cancer process. Since the first mutations were described, several attempts to establish genotype-phenotype correlations for these genetic alterations have been reported. Moreover, in vitro data have suggested effects of mutant proteins in proliferation. Genotype-phenotype correlations are not only important for predicting the clinical course of the disease and to allow tailor-made surveillance of individuals at risk, but also have implications for the elucidation of the molecular genetic mechanisms underlying genesis of cancer and the development of gene-based therapies. Here, we discuss genotype-phenotype correlation of cancer in mouse and man, and the functional aspects that may account for these observations important to both understand and treat the human disease process.

Keywords: mouse models, drug discovery, cancer process, cancer target cell, differentiation

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Article Details

VOLUME: 6
ISSUE: 2
Year: 2005
Page: [81 - 88]
Pages: 8
DOI: 10.2174/1389202053642276
Price: $58