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Current Organic Chemistry

Editor-in-Chief

ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

Advanced Methods for the Synthesis of 3-Substituted 1H-Isoindol-1-Ones

Author(s): Geza Stajer and Ferenc Csende

Volume 9, Issue 13, 2005

Page: [1277 - 1286] Pages: 10

DOI: 10.2174/1385272054863952

Price: $65

Abstract

Both direct and multistep reactions, involving the application of carbonyl compounds, e. g. oxoacids, phthalimides, 2-iodobenzamides or acylhalides, have been developed as novel synthetic routes for the preparation of 3- substituted 2,3-dihydro-1H-isoindol-1-ones, which are reviewed here. Alternatively, reductive or acid-catalyzed rearrangements of certain heterocycles lead to the formation of 3-substituted isoindolones. Asymmetric syntheses too have been described.

Keywords: isoindolones, dearomatization, heteroannulation, baylis-hillman reaction, magnesium monoperoxyphthalate, dicarbonyl compounds

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