Advanced Methods for the Synthesis of 3-Substituted 1H-Isoindol-1-Ones | BenthamScience

Advanced Methods for the Synthesis of 3-Substituted 1H-Isoindol-1-Ones

Author(s): Geza Stajer, Ferenc Csende.

Journal Name: Current Organic Chemistry

Volume 9 , Issue 13 , 2005

Abstract:

Both direct and multistep reactions, involving the application of carbonyl compounds, e. g. oxoacids, phthalimides, 2-iodobenzamides or acylhalides, have been developed as novel synthetic routes for the preparation of 3- substituted 2,3-dihydro-1H-isoindol-1-ones, which are reviewed here. Alternatively, reductive or acid-catalyzed rearrangements of certain heterocycles lead to the formation of 3-substituted isoindolones. Asymmetric syntheses too have been described.

Keywords: isoindolones, dearomatization, heteroannulation, baylis-hillman reaction, magnesium monoperoxyphthalate, dicarbonyl compounds

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Article Details

VOLUME: 9
ISSUE: 13
Year: 2005
Page: [1277 - 1286]
Pages: 10
DOI: 10.2174/1385272054863952
Price: $58

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