The Clinical Genetics of Psoriasis

Author(s): E. Campalani, J. N.W.N. Barker.

Journal Name: Current Genomics

Volume 6 , Issue 1 , 2005

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Abstract:

Psoriasis is a common chronic inflammatory disease of the skin affecting approximately 2% of Caucasians. Psoriasis has a worldwide distribution, with prevalence varying according to race and geographic location. Numerous population-, family- and twin-based studies point to a very strong genetic component of this disease. Psoriasis is a complex disease, as suggested by a very unclear and variable pattern of inheritance and a higher frequency in families of dizygotic twins than in those of monozygotic twins. So far 9 psoriasis susceptibility loci have been identified (PSORS1-9) but only three (PSORS1, PSORS2 and PSORS4) have been replicated in more than one study. The strongest genetic association has been found with the HLA-C region on the short arm of chromosome 6. Failure to reach 100% concordance in monozygotic twins points to a multifactorial aetiology of psoriasis where environmental factors play an important role in genetically predisposed individuals. Clinical, histological and ultrastructural evidence suggests that psoriasis is a T cellmediated disease where T cell activation is followed by release of pro-inflammatory cytokines, leukocytic infiltration of the skin, abnormal keratinocyte proliferation and angiogenesis. It is not known which exogenous or endogenous antigen(s) is responsible for triggering T cell activation or which genes play a fundamental role in psoriasis. Research is being carried out in an attempt to answer these questions. Here we review the main pathogenetic and epidemiological aspects of this skin condition.

Keywords: psoriasis, epidemiology, prevalence, genetics, pathogenesis, multifactorial disease

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Article Details

VOLUME: 6
ISSUE: 1
Year: 2005
Page: [51 - 60]
Pages: 10
DOI: 10.2174/1389202053202157

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