Genes Involved in Apoptosis Regulation: Implications for Cancer Therapy

Author(s): Simone Fulda, Klaus-Michael Debatin.

Journal Name: Current Genomics

Volume 6 , Issue 8 , 2005

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Abstract:

Apoptosis, the cells intrinsic death program, plays an important role in the regulation of tissue homeostasis. Also, killing of cancer cells by various cytotoxic approaches such as anticancer drugs, γ-irradiation, suicide genes or immunotherapy, is predominantly mediated through induction of apoptosis in target cells. Understanding the molecular events that regulate apoptosis and how tumor cells evade apoptotic deletion have provided a paradigm to link cancer genetics and response to cancer therapy. Thus, insights into the mechanisms regulating drug-induced apoptosis provide rational targets for novel therapeutic interventions.

Keywords: Apoptosis, cancer, IAP, Bcl-2

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Article Details

VOLUME: 6
ISSUE: 8
Year: 2005
Page: [609 - 611]
Pages: 3
DOI: 10.2174/138920205775811407
Price: $58