Current Gene Therapy

Ignacio Anegon
Director INSERM UMR 1064-Center for Research in Transplantation and Immunology
CHU de Nantes. 30, boulevard
Nantes
France

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Tumour Gene Therapy Monitoring Using Magnetic Resonance Imaging and Spectroscopy

Author(s): Mikko I. Kettunen, Olli H.J. Grohn.

Abstract:

Recent progress in gene therapy has increased the need for non-invasive imaging methods that would allow early diagnosis of successful treatment. Magnetic resonance methods, magnetic resonance imaging (MRI) and spectroscopy (MRS), have shown great promise to achieve this goal. The current mini-review describes recent advances in experimental MRI and MRS to detect individual treatment steps in gene therapy of tumours from gene transfection to therapy response. Limitations of the current techniques are also discussed.

Keywords: Diffusion, relaxation, T1r, lipids, molecular imaging

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Article Details

VOLUME: 5
ISSUE: 6
Year: 2005
Page: [685 - 696]
Pages: 12
DOI: 10.2174/156652305774964686
Price: $58