Abstract
The glycosyltransferase enzyme LgtA, derived from the bacterial pathogen Neisseria meningitidis, was utilised in the chemo-enzymatic synthesis of a trisaccharide-linked endomorphin peptide drug candidate.
Keywords: glycosyltransferase, oligosaccharide, chemo-enzymatic, glycopeptide, solid-phase synthesis, endomorphin, peptide drug delivery, drug targeting
Current Drug Delivery
Title: Chemo-Enzymatic Synthesis of a Trisaccharide-Linked Peptide Aimed at Improved Drug-Delivery
Volume: 2 Issue: 3
Author(s): Ken D. Johnstone, Manuela Dieckelmann, Michael P. Jennings, Istvan Toth and Joanne T. Blanchfield
Affiliation:
Keywords: glycosyltransferase, oligosaccharide, chemo-enzymatic, glycopeptide, solid-phase synthesis, endomorphin, peptide drug delivery, drug targeting
Abstract: The glycosyltransferase enzyme LgtA, derived from the bacterial pathogen Neisseria meningitidis, was utilised in the chemo-enzymatic synthesis of a trisaccharide-linked endomorphin peptide drug candidate.
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Cite this article as:
Johnstone D. Ken, Dieckelmann Manuela, Jennings P. Michael, Toth Istvan and Blanchfield T. Joanne, Chemo-Enzymatic Synthesis of a Trisaccharide-Linked Peptide Aimed at Improved Drug-Delivery, Current Drug Delivery 2005; 2 (3) . https://dx.doi.org/10.2174/1567201054367977
DOI https://dx.doi.org/10.2174/1567201054367977 |
Print ISSN 1567-2018 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5704 |
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