Current Drug Delivery

Istvan Toth
School of Pharmacy,University of Queensland
Brisbane, 4072
Australia

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Chemo-Enzymatic Synthesis of a Trisaccharide-Linked Peptide Aimed at Improved Drug-Delivery

Author(s): Ken D. Johnstone, Manuela Dieckelmann, Michael P. Jennings, Istvan Toth and Joanne T. Blanchfield

Affiliation: School of Molecular and Microbial Sciences, University of Queensland, St. Lucia 4072, Qld, Australia.

Abstract:

The glycosyltransferase enzyme LgtA, derived from the bacterial pathogen Neisseria meningitidis, was utilised in the chemo-enzymatic synthesis of a trisaccharide-linked endomorphin peptide drug candidate.

Keywords: glycosyltransferase, oligosaccharide, chemo-enzymatic, glycopeptide, solid-phase synthesis, endomorphin, peptide drug delivery, drug targeting

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Article Details

VOLUME: 2
ISSUE: 3
Page: [215 - 222]
Pages: 8
DOI: 10.2174/1567201054367977
Price: $58