Chemo-Enzymatic Synthesis of a Trisaccharide-Linked Peptide Aimed at Improved Drug-Delivery
Ken D. Johnstone, Manuela Dieckelmann, Michael P. Jennings, Istvan Toth and Joanne T. Blanchfield
Affiliation: School of Molecular and Microbial Sciences, University of Queensland, St. Lucia 4072, Qld, Australia.
The glycosyltransferase enzyme LgtA, derived from the bacterial pathogen Neisseria meningitidis, was utilised in the chemo-enzymatic synthesis of a trisaccharide-linked endomorphin peptide drug candidate.
Keywords: glycosyltransferase, oligosaccharide, chemo-enzymatic, glycopeptide, solid-phase synthesis, endomorphin, peptide drug delivery, drug targeting
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