Peptoids As Source of Compounds Eliciting Antibacterial Activity

Author(s): Isabel Masip, Enrique Perez-Paya, Angel Messeguer.

Journal Name: Combinatorial Chemistry & High Throughput Screening
Accelerated Technologies for Biotechnology, Bioassays, Medicinal Chemistry and Natural Products Research

Volume 8 , Issue 3 , 2005

Become EABM
Become Reviewer


N-Alkylglycine oligomers (peptoids) constitute a family of non-natural peptidomimetics attractive for the early drug discovery process because of their physicochemical features, easy of adaptation to combinatorial chemistry approaches and their proteolytic stability. Consequently, peptoid libraries have found application for discovering hits against a wide diversity of pharmaceutical targets, among which different examples of antibacterials are found. In the present work, research efforts addressed towards the identification of peptoids as antibacterial agents are discussed.

Keywords: n-alkylglycine trimers, peptoids, combinatorial chemistry, chemical libraries, antibacterial activity, bacterial resistance

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2005
Page: [235 - 239]
Pages: 5
DOI: 10.2174/1386207053764567
Price: $58

Article Metrics

PDF: 6