Combinatorial Chemistry & High Throughput Screening

Rathnam Chaguturu 
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Peptoids As Source of Compounds Eliciting Antibacterial Activity

Author(s): Isabel Masip, Enrique Perez-Paya and Angel Messeguer

Affiliation: Department of Biological Organic Chemistry, I.I.Q.A.B. (C.S.I.C.). J. Girona, 18. E-08034 Barcelona, Spain.

Keywords: n-alkylglycine trimers, peptoids, combinatorial chemistry, chemical libraries, antibacterial activity, bacterial resistance

Abstract:

N-Alkylglycine oligomers (peptoids) constitute a family of non-natural peptidomimetics attractive for the early drug discovery process because of their physicochemical features, easy of adaptation to combinatorial chemistry approaches and their proteolytic stability. Consequently, peptoid libraries have found application for discovering hits against a wide diversity of pharmaceutical targets, among which different examples of antibacterials are found. In the present work, research efforts addressed towards the identification of peptoids as antibacterial agents are discussed.

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Article Details

VOLUME: 8
ISSUE: 3
Page: [235 - 239]
Pages: 5
DOI: 10.2174/1386207053764567