Current Medicinal Chemistry

Atta-ur-Rahman, FRS
Honorary Life Fellow
Kings College
University of Cambridge


Transcription Factor Therapeutics: Long-shot or Lodestone

Author(s): David Ghosh and Athanasios G. Papavassiliou

Affiliation: Institute for Transcriptional Informatics, P.O. Box. 2556, Pittsburgh, PA. 15230-2556, USA.


Many drugs, both approved and in development, exert their effects through transcription factors. The complexity of the biology of transcriptional regulation, however, presents challenges to the effective design of therapies that directly target transcription factors. This review focuses on the different approaches that are currently pursued in therapeutics and drug discovery aimed at targeting transcription factors and signaling molecules, and their areas of effect in transcription factor biology. A relatively recent approach termed “transcription therapy” has been applied for a number of drugs in development, which may potentially provide a new avenue for targeting transcription factors for therapeutic purposes.

Keywords: transcription factors, drug discovery, gene regulation, gene networks, promoters

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Article Details

Page: [691 - 701]
Pages: 11
DOI: 10.2174/0929867053202197
Price: $58