Betulinic Acid and Its Derivatives: A Review on their Biological Properties

Author(s): Perumal Yogeeswari, Dharmarajan Sriram.

Journal Name: Current Medicinal Chemistry

Volume 12 , Issue 6 , 2005


Betulinic acid is a naturally occurring pentacyclic triterpenoid and has been shown to exhibit a variety of biological activities including inhibition of human immunodeficiency virus (HIV), antibacterial, antimalarial, antiinflammatory, anthelmintic and antioxidant properties. This article reports a survey of the literature dealing with betulinic acid related biological properties that has appeared from the 1990s to the beginning of 2003. A broad range of medical and pharmaceutical disciplines are covered, including a brief introduction about discovery, phytochemical aspects, organic synthesis, anti-HIV and cytotoxic mechanisms of action. Various structural modifications carried out and their biological and pharmacokinetic profiles are also incorporated.

Keywords: betulinic acid, anti-hiv derivatives, anti-hiv mechanism, anticancer derivatives, anticancer mechanism, antiinflammatory, antimalarial, biotransformation

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Article Details

Year: 2005
Page: [657 - 666]
Pages: 10
DOI: 10.2174/0929867053202214
Price: $65

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PDF: 39