Abstract
Quassinoids are highly oxygenated triterpenes, which were isolated as bitter principles from the plants of Simaroubaceae family. Their synthesis has attracted much attention because of the wide spectrum of their biological properties. The most prevalent quassinoids have C-20 picrasane skeleton, some known as bruceolides as they were isolated from the genus Brucea, which showed marked antileukemic and antimalarial activities.
Keywords: quassinoids, semi-synthesis, total synthesis, biological activities, sar, antileukemic and antimalarial activities
Current Medicinal Chemistry
Title: Biologically Active Quassinoids and Their Chemistry: Potential Leads for Drug Design
Volume: 12 Issue: 2
Author(s): Z. Guo, S. Vangapandu, R. W. Sindelar, L. A. Walker and R. D. Sindelar
Affiliation:
Keywords: quassinoids, semi-synthesis, total synthesis, biological activities, sar, antileukemic and antimalarial activities
Abstract: Quassinoids are highly oxygenated triterpenes, which were isolated as bitter principles from the plants of Simaroubaceae family. Their synthesis has attracted much attention because of the wide spectrum of their biological properties. The most prevalent quassinoids have C-20 picrasane skeleton, some known as bruceolides as they were isolated from the genus Brucea, which showed marked antileukemic and antimalarial activities.
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Cite this article as:
Guo Z., Vangapandu S., Sindelar W. R., Walker A. L. and Sindelar D. R., Biologically Active Quassinoids and Their Chemistry: Potential Leads for Drug Design, Current Medicinal Chemistry 2005; 12 (2) . https://dx.doi.org/10.2174/0929867053363351
DOI https://dx.doi.org/10.2174/0929867053363351 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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