Immunity to Tumour Antigens

Author(s): G. Li , S. A. Ali , S. E.B. McArdle , S. Mian , M. Ahmad , A. Miles , R. C. Rees .

Journal Name: Current Pharmaceutical Design

Volume 11 , Issue 27 , 2005

Abstract:

During the last decade, a large number of human tumour antigens have been identified. These antigens are classified as tumour-specific shared antigens, tissue-specific differentiation antigens, overexpressed antigens, tumour antigens resulting from mutations, viral antigens and fusion proteins. Antigens recognised by effectors of immune system are potential targets for antigen-specific cancer immunotherapy. However, most tumour antigens are self-proteins and are generally of low immunogenicity and the immune response elicited towards these tumour antigens is not always effective. Strategies to induce and enhance the tumour antigen-specific response are needed. This review will summarise the approaches to discovery of tumour antigens, the current status of tumour antigens, and their potential application to cancer treatment.

Keywords: tumour antigen, immunotherapy, antigen discovery, tolerance

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Article Details

VOLUME: 11
ISSUE: 27
Year: 2005
Page: [3501 - 3509]
Pages: 9
DOI: 10.2174/138161205774414583
Price: $58

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