Abstract
Tuberculosis vaccine research began with the search for a vaccine that might be better than, and thus could replace, the current Bacillus Calmette Guérin (BCG) vaccine. Over the last fifteen years or so, intense research effort has led to the identification of a number of novel tuberculosis (TB) vaccines which can be divided into 4 categories: genetically modified mycobacteria, protein, plasmid DNA and viral. However, it is increasingly believed that the current BCG vaccine will continue to be used as a childhood vaccine and that more effort should be directed to developing appropriate boosting vaccines. Mounting evidence suggests that recombinant genetic vaccines, particularly recombinant viral vaccines, are effective in boosting immune activation and protection by BCG vaccination. Since modified vaccinia virus Ankara (MVA)- and adenovirus-vectored TB vaccines have been most extensively studied, this review will focus on recent advances in the development and applications of these two viral TB vaccines.
Keywords: modified vaccinia virus Ankara, cmv promoters, gag gene, bcg vaccination, bovine models, genetically modified dendritic cell, immunopathology
Current Gene Therapy
Title: Recent Advances in the Development of Adenovirus- and Poxvirus- Vectored Tuberculosis Vaccines
Volume: 5 Issue: 5
Author(s): Zhou Xing, Michael Santosuosso, Sarah McCormick, Teng-Chih Yang, James Millar, Mary Hitt, Yonghong Wan, Jonathan Bramson and H. M. Vordermeier
Affiliation:
Keywords: modified vaccinia virus Ankara, cmv promoters, gag gene, bcg vaccination, bovine models, genetically modified dendritic cell, immunopathology
Abstract: Tuberculosis vaccine research began with the search for a vaccine that might be better than, and thus could replace, the current Bacillus Calmette Guérin (BCG) vaccine. Over the last fifteen years or so, intense research effort has led to the identification of a number of novel tuberculosis (TB) vaccines which can be divided into 4 categories: genetically modified mycobacteria, protein, plasmid DNA and viral. However, it is increasingly believed that the current BCG vaccine will continue to be used as a childhood vaccine and that more effort should be directed to developing appropriate boosting vaccines. Mounting evidence suggests that recombinant genetic vaccines, particularly recombinant viral vaccines, are effective in boosting immune activation and protection by BCG vaccination. Since modified vaccinia virus Ankara (MVA)- and adenovirus-vectored TB vaccines have been most extensively studied, this review will focus on recent advances in the development and applications of these two viral TB vaccines.
Export Options
About this article
Cite this article as:
Xing Zhou, Santosuosso Michael, McCormick Sarah, Yang Teng-Chih, Millar James, Hitt Mary, Wan Yonghong, Bramson Jonathan and Vordermeier M. H., Recent Advances in the Development of Adenovirus- and Poxvirus- Vectored Tuberculosis Vaccines, Current Gene Therapy 2005; 5 (5) . https://dx.doi.org/10.2174/156652305774329230
DOI https://dx.doi.org/10.2174/156652305774329230 |
Print ISSN 1566-5232 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5631 |
Call for Papers in Thematic Issues
Programmed Cell Death Genes in Oncology: Pioneering Therapeutic and Diagnostic Frontiers (BMS-CGT-2024-HT-45)
Programmed Cell Death (PCD) is recognized as a pivotal biological mechanism with far-reaching effects in the realm of cancer therapy. This complex process encompasses a variety of cell death modalities, including apoptosis, autophagic cell death, pyroptosis, and ferroptosis, each of which contributes to the intricate landscape of cancer development and ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Anti-Tuberculosis
Current Bioactive Compounds Immunity to Bacterial Infections
Current Immunology Reviews (Discontinued) Surfactant Therapy of Pulmonary Conditions Excluding those with Primary Surfactant Deficiency and Bronchoscopy as Delivery Method: An Overview of Russian Patents and Publications
Recent Patents on Drug Delivery & Formulation Mannose Binding Lectin: A Potential Biomarker for Many Human Diseases
Current Medicinal Chemistry Cancer Immunotherapy: Battling Tumors with Gene Vaccines
Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents Terpenoids form the Sea: Chemical Diversity and Bioactivity
Current Organic Chemistry A Novel Advanced Laboratory Diagnosis to Guide Tuberculosis Drug Therapy.
Recent Patents on Anti-Infective Drug Discovery Kinase Targets for Mycolic Acid Biosynthesis in Mycobacterium tuberculosis
Current Molecular Pharmacology Controlling Biofilms of Gram-Positive Pathogenic Bacteria
Current Medicinal Chemistry Structural Biology of Bacterial Iron Uptake Systems
Current Topics in Medicinal Chemistry Design, Synthesis and Evaluation of Thiourea Derivatives as Antimicrobial and Antiviral Agents
Letters in Drug Design & Discovery Metal-Based Antimicrobial Protease Inhibitors
Current Medicinal Chemistry Personalized Drug Discovery: HCA Approach Optimized for Rare Diseases at Tel Aviv University
Combinatorial Chemistry & High Throughput Screening Shikimate Kinase: A Potential Target for Development of Novel Antitubercular Agents
Current Drug Targets Antimicrobial Effects of Chemical Compounds Isolated from Traditional Chinese Herbal Medicine (TCHM) Against Drug-Resistant Bacteria: A Review Paper
Mini-Reviews in Medicinal Chemistry Molecular Modeling Used to Evaluate CYP2C9-Dependent Metabolism: Homology Modeling, Molecular Dynamics and Docking Simulations
Current Drug Metabolism The Application of Xpert Mycobacterium tuberculosis/Rifampicin, Quantitative Polymerase Chain Reaction and High Resolution Melting Curve in the Diagnosis of Superficial Lymph Node TB.
Current Pharmaceutical Biotechnology Insights into Novel Coronavirus Disease 2019 (COVID-19): Current Understanding, Research, and Therapeutic Updates
Recent Patents on Biotechnology Methylenetetrahydrofolate Reductase: Biochemical Characterization and Medical Significance
Current Pharmaceutical Design Association of N-Acetyltransferase-2 Genotypes and Anti-Tuberculosis Induced Liver Injury: First Case-Controlled Study from Iran
Current Drug Safety