Current Cancer Drug Targets

Ruiwen Zhang 
Texas Tech University Health Sciences Center
1300 Coulter Drive
Amarillo, TX 79106


Squalamine: A Polyvalent Drug of the Future?

Author(s): Jean Michel Brunel, Chanaz Salmi, Celine Loncle, Nicolas Vidal, Yves Letourneux.


The purpose of this mini-review is to summarize and highlight the different advances in our understanding of the antimicrobial and antiangiogenic activity of squalamine, a cationic steroid isolated in 1993 from the dogfish shark Squalus Acanthias. Indeed, squalamine has shown to be useful for the treatment of important diseases such as cancers (lung, ovarian, brain and others), age-related macular degeneration (AMD) and the control of body weight in man. All these results led to a question: could we consider squalamine as a polyvalent drug of the future?

Keywords: squalamine, aminosterol, cancer, age-related macular degeneration (amd), appetite suppression, weight reduction

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Article Details

Year: 2005
Page: [267 - 272]
Pages: 6
DOI: 10.2174/1568009054064642
Price: $58