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Current Organic Chemistry

Editor-in-Chief

ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

Pyrroloiminoquinone Alkaloids: Discorhabdins and Makaluvamines

Author(s): Yu Harayama and Yasuyuki Kita

Volume 9, Issue 15, 2005

Page: [1567 - 1588] Pages: 22

DOI: 10.2174/138527205774370568

Price: $65

Abstract

The pyrroloiminoquinone alkaloid family consisting of discorhabdins and makaluvamines exhibits antitumor activities derived from their unique highly-fused structures. The total synthesis of them and the key reactions used in the total synthesis of these compounds are described.

Keywords: discorhabdin c, yamamura's synthesis, heathcock's synthesis, white's formal synthesis, makaluvamine a, kraus's synthesis


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