Chemistry of Indole Alkaloids Related to the Corynanthe-Type from Uncaria, Nauclea and Mitragyna Plants

Author(s): Hiromitsu Takayama, Mariko Kitajima, Noriyuki Kogure.

Journal Name: Current Organic Chemistry

Volume 9 , Issue 15 , 2005

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Abstract:

A number of monoterpenoid indole and oxindole alkaloids have been isolated from botanical sources, and many of them have been found to possess significant pharmacological activities and are utilized as key lead compounds in new drug development. In this review, the recent results of our phytochemical and synthetic studies of indole alkaloids having the Corynanthe-type related skeleton from genera Uncaria, Nauclea, and Mitragyna, which are classified under tribe Cinchoneae, family Rubiaceae, are described.

Keywords: cinchonoideae, indole alkaloids, isocorynoxeine, facile interconversion, ophiorrhiza plants, nmda receptor

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Article Details

VOLUME: 9
ISSUE: 15
Year: 2005
Page: [1445 - 1464]
Pages: 20
DOI: 10.2174/138527205774370559
Price: $58

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