Login

Journal Image
Current Molecular Medicine
ISSN (Print): 1566-5240
ISSN (Online): 1875-5666
VOLUME: 5
ISSUE: 3
DOI: 10.2174/1566524053766095      Price:  $58









Type 2 Diabetes As An Inflammatory Cardiovascular Disorder

img
Author(s): D. Ziegler
Pages 309-322 (14)
Abstract:
Type 2 diabetes carries a 2-6-fold increased risk of cardiovascular disease (CVD) and death. Indeed, the risk of major cardiovascular events in Type 2 diabetic patients without history of coronary heart disease (CHD) is equivalent to that observed in non-diabetic subjects with CHD. However, atherosclerosis may also precede the development of diabetes, suggesting that both disorders share common genetic and environmental antecedent factors (“common soil” hypothesis). One such a possible ancestor is insulin resistance which constitutes both a major feature of Type 2 diabetes and an independent risk factor for CHD. It is well documented that inflammatory processes play an important role in the causation of atherosclerotic CVD. Inflammatory mediators play a paramount role in the initiation, progression, and rupture of atherosclerotic plaques. Thus, markers of
Keywords:
atherosclerosis, inflammation, macrophages, high sensitivity c-reactive protein (hscrp), low-density lipoprotein (ldl) cholesterol, leukocyte, chemoattraction, interferon, angistensin, crp-transgenic (crp-tg) mouse model
Affiliation:
Deutsche Diabetes-Klinik, Deutsches Diabetes-Zentrum, Leibniz-Zentrum an der Heinrich-Heine- Universitat, Auf'm Hennekamp 65, 40225 Dusseldorf, Germany.