Current Drug Targets

Francis J. Castellino
Kleiderer-Pezold Professor of Biochemistry
Director, W.M. Keck Center for Transgene Research
Dean Emeritus, College of Science
230 Raclin-Carmichael Hall, University of Notre Dame
Notre Dame, IN 46556
USA

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Currently Used Antimycotics: Spectrum, Mode of Action and Resistance Occurrence

Author(s): Isabelle E.J.A. Francois, An M. Aerts, Bruno P.A. Cammue, Karin Thevissen.

Abstract:

The increasing incidence of fungal infections combined with the emerging problem of antifungal drug resistance have prompted investigations of the mode of action of the currently used antifungal therapeutics (antimycotics). The routinely used antimycotics can be grouped into six different classes based on their mode of action. In this review, the mode of action and antifungal spectrum of these classes are discussed, together with possible resistance development against them.

Keywords: Griseofulvin, 5-FC, echinocandins, allylamines, polyenes, azoles

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Article Details

VOLUME: 6
ISSUE: 8
Year: 2005
Page: [895 - 907]
Pages: 13
DOI: 10.2174/138945005774912744
Price: $58