Hypoxia as an Initiator of Neuroinflammation: Microglial Connections

Author(s): Jiyeon Ock , Hee-Jung Cho , Su Hyung Hong , In Kyeom Kim , Kyoungho Suk .

Journal Name: Current Neuropharmacology

Volume 3 , Issue 2 , 2005

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Abstract:

Hypoxia, which is a lowered physiological oxygen tension, is an important biological signal as well as a component of many diseases. In central nervous system, hypoxia is associated with brain injury following the ischemic stroke. Recent studies indicate that hypoxia may not only induce a direct neuronal damage, but it may also initiate inflammatory responses by activating microglia. Toxic inflammatory mediators produced by activated microglia under hypoxic conditions exacerbate the neuronal injury during cerebral ischemia. Pharmacological inhibition of hypoxic activation of microglia may prove to be neuroprotective against ischemic stroke.

Keywords: hypoxia, microglia, inflammation, apoptosis, neurodegeneration, neuronal injury, ischemia

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Article Details

VOLUME: 3
ISSUE: 2
Year: 2005
Page: [183 - 191]
Pages: 9
DOI: 10.2174/1570159053586681
Price: $58

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