Abstract
Transgenic and knockout mice are created and used for a large variety of research objectives. This overview describes the (genetically modified) mouse models that have been used to study the development of myocardial ischemia and reperfusion injury. The role of cytokines, chemokines, leukocytes, reactive oxygen species, anti-oxidants, NO, complement system, coagulation system, heat shock proteins, apoptosis and necrosis, and acute phase reactants are presented.
Keywords: Myocardial, ischemia, reperfusion, mice, inflammation, overexpression, knockout, transgene
Current Genomics
Title: Myocardial Ischemia and Reperfusion Injury: Studies Using Transgenic and Knockout Mice
Volume: 6 Issue: 6
Author(s): W. M.C. Jong, H. T. Cate, P. H. Reitsma and R. J. de Winter
Affiliation:
Keywords: Myocardial, ischemia, reperfusion, mice, inflammation, overexpression, knockout, transgene
Abstract: Transgenic and knockout mice are created and used for a large variety of research objectives. This overview describes the (genetically modified) mouse models that have been used to study the development of myocardial ischemia and reperfusion injury. The role of cytokines, chemokines, leukocytes, reactive oxygen species, anti-oxidants, NO, complement system, coagulation system, heat shock proteins, apoptosis and necrosis, and acute phase reactants are presented.
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Cite this article as:
Jong M.C. W., Cate T. H., Reitsma H. P. and de Winter J. R., Myocardial Ischemia and Reperfusion Injury: Studies Using Transgenic and Knockout Mice, Current Genomics 2005; 6 (6) . https://dx.doi.org/10.2174/138920205774482990
DOI https://dx.doi.org/10.2174/138920205774482990 |
Print ISSN 1389-2029 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5488 |
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