Post-assembly Peptide Modifications by Chemical Methods

Author(s): Sambasivarao Kotha, Kakali Lahiri.

Journal Name: Current Medicinal Chemistry

Volume 12 , Issue 7 , 2005

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Abstract:

The demand for peptide drugs is increasing and in this context, “post-assembly (or posttranslational) peptide modification strategies” by chemical manipulation of intact oligo-peptides has provided several analogues. Compounds prepared by this method are useful therapeutic molecules for structure activity studies. Herein, we describe various chemical methods such as cross-coupling reactions, cycloaddition reactions, radical reactions and ring-closing metathesis reactions that are useful for posttranslational peptide modifications.

Keywords: sequencing, human genome, peptide, oxidation, biomimetic cyclization, crosscoupling reactions, photoaffinity

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Article Details

VOLUME: 12
ISSUE: 7
Year: 2005
Page: [849 - 875]
Pages: 27
DOI: 10.2174/0929867053507333
Price: $58

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