Current Medicinal Chemistry

Atta-ur-Rahman, FRS
Honorary Life Fellow
Kings College
University of Cambridge
Cambridge
UK

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Fluorescence Imaging of Tumors In Vivo

Author(s): Byron Ballou, Lauren A. Ernst and Alan S. Waggoner

Affiliation: Molecular Biosensor and Imaging Center, Carnegie Mellon University, 4400 Fifth Avenue, Pittsburgh, PA 15213, USA.

Keywords: animals, antibodies, monoclonal, antigens, neoplasm, fluorescent dyes, green fluorescent protein, imaging, nanotechnology, quantum dots

Abstract:

We review recent progress in tumor imaging in vivo using fluorescent tags, highlight the problems of fluorescence imaging in small animals, discuss recent advances in near-infrared fluorochromes and quantum dots, and point to some future possibilities. GFP-based fluorescence imaging is briefly discussed. The authors believe that improvements in near-infrared fluorochromes are required to enable practical imaging in tissues at centimeter depths.

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Article Details

VOLUME: 12
ISSUE: 7
Page: [795 - 805]
Pages: 11
DOI: 10.2174/0929867053507324