Synthesis and QSAR Studies on Thiazolidinones as Anti-HIV Agents

Author(s): Ravindra K. Rawal, V. R. Solomon, Yenamandra S. Prabhakar, S. B. Katti, E. De Clercq.

Journal Name:Combinatorial Chemistry & High Throughput Screening

Volume 8 , Issue 5 , 2005

Abstract:

selected 4-thiazolidinone have been synthesized and tested as anti-HIV activity. The results of the in vitro tests showed that one of the compounds, 5, inhibited the enzyme at 0.204μM concentration with minimal toxicity to MT-4 cell. Furthermore, the QSAR studies indicated the role of PMIZ, Ovality and Total energy content of the compounds in rationalizing the activity.

Keywords: thiazolidinones, metathiazanones, anti-hiv agents, nnrtis, dicyclohexylcarbodiimide (dcc)

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Article Details

VOLUME: 8
ISSUE: 5
Year: 2005
Page: [439 - 443]
Pages: 5
DOI: 10.2174/1386207054546496
Price: $58