Abstract
In multicellular organisms, unnecessary or harmful cells, such as those that are cancerous or infected with a virus, are eliminated by apoptosis. After apoptosis, cell corpses are rapidly recognized and phagocytosed by professional phagocytes, such as macrophages and dendritic cells. The rapid removal of cell corpses by phagocytes prevents the release of potentially toxic or immunogenic materials from dying cells. Although a number of molecules on phagocytes have been found to be involved in apoptotic cell clearance in vitro, only a few have been proved to be involved in apoptotic cell clearance in vivo by analyses of knockout animals. These knockout mice commonly suffer from autoimmunity, indicating that the complete removal of apoptotic cells is essential for the maintenance of selftolerance. In this review, we present an overview of the molecular mechanisms of apoptotic cell clearance by phagocytes and the pathological relevance of the failure of apoptotic cell clearance to autoimmune disorder.
Keywords: Apoptosis, phagocytosis, macrophage, dendritic cell, autoimmune disease, self-tolerance
Current Medicinal Chemistry
Title: Apoptotic Cell Clearance and Autoimmune Disorder
Volume: 14 Issue: 27
Author(s): Masato Tanaka and Yasunobu Miyake
Affiliation:
Keywords: Apoptosis, phagocytosis, macrophage, dendritic cell, autoimmune disease, self-tolerance
Abstract: In multicellular organisms, unnecessary or harmful cells, such as those that are cancerous or infected with a virus, are eliminated by apoptosis. After apoptosis, cell corpses are rapidly recognized and phagocytosed by professional phagocytes, such as macrophages and dendritic cells. The rapid removal of cell corpses by phagocytes prevents the release of potentially toxic or immunogenic materials from dying cells. Although a number of molecules on phagocytes have been found to be involved in apoptotic cell clearance in vitro, only a few have been proved to be involved in apoptotic cell clearance in vivo by analyses of knockout animals. These knockout mice commonly suffer from autoimmunity, indicating that the complete removal of apoptotic cells is essential for the maintenance of selftolerance. In this review, we present an overview of the molecular mechanisms of apoptotic cell clearance by phagocytes and the pathological relevance of the failure of apoptotic cell clearance to autoimmune disorder.
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Cite this article as:
Tanaka Masato and Miyake Yasunobu, Apoptotic Cell Clearance and Autoimmune Disorder, Current Medicinal Chemistry 2007; 14 (27) . https://dx.doi.org/10.2174/092986707782360006
DOI https://dx.doi.org/10.2174/092986707782360006 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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