Abstract
Neuraminidase is a major glycoprotein of influenza virus which is essential for viral infection and offers a potential target for antiviral drug development. Rational drug design of NA inhibitors is now in the clinic and these molecules are effective and safe for the treatment of influenza. Recently, research of structure-based NA inhibitors is becoming an interesting field, leading to a breakthrough in the control of influenza. Here we review the progress in the rational drug design of NA inhibitors in recent years.
Keywords: Influenza virus, neuraminidase, neuraminidase inhibitor, pharmacophore model, antiviral agent
Current Medicinal Chemistry
Title: Recent Progress in Rational Drug Design of Neuraminidase Inhibitors
Volume: 14 Issue: 27
Author(s): Yu Liu, Jie Zhang and Wenfang Xu
Affiliation:
Keywords: Influenza virus, neuraminidase, neuraminidase inhibitor, pharmacophore model, antiviral agent
Abstract: Neuraminidase is a major glycoprotein of influenza virus which is essential for viral infection and offers a potential target for antiviral drug development. Rational drug design of NA inhibitors is now in the clinic and these molecules are effective and safe for the treatment of influenza. Recently, research of structure-based NA inhibitors is becoming an interesting field, leading to a breakthrough in the control of influenza. Here we review the progress in the rational drug design of NA inhibitors in recent years.
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Cite this article as:
Liu Yu, Zhang Jie and Xu Wenfang, Recent Progress in Rational Drug Design of Neuraminidase Inhibitors, Current Medicinal Chemistry 2007; 14 (27) . https://dx.doi.org/10.2174/092986707782360024
DOI https://dx.doi.org/10.2174/092986707782360024 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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