Manipulation of Microglial Activation as a Therapeutic Strategy in Alzheimers Disease

Author(s): Feng-Shiun Shie, Randall L. Woltjer.

Journal Name: Current Medicinal Chemistry

Volume 14 , Issue 27 , 2007

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Abstract:

Alzheimers disease (AD) is the leading cause of dementia. Although the etiology of AD remains controversial, the amyloid hypothesis suggests that β-amyloid (Aβ) peptides may contribute to brain dysfunction, and microglial activation has become increasingly regarded as a potential contributor to disease pathogenesis. Microglial activation is characterized by morphological changes and by production of various effectors, and activated neuroinflammation concurrent with increased oxidative stress may contribute to damage to neurons. However, recently there has been a recognition that microglia may also play a neuroprotective role through their release of neurotrophic factors and through phagocytosis of Aβ. Thus, there is growing consensus that a favorable combination of diminished microglia- mediated neuroinflammation and enhanced Aβ clearance may be critical in AD therapy. In this review, we will discuss the role of microglial activation in AD and how pharmacologic manipulation of microglia might bear upon the treatment of AD.

Keywords: Alzheimer's disease, microglial activation, neuroinflammation, beta-amyloid, tau, therapy

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Article Details

VOLUME: 14
ISSUE: 27
Year: 2007
Page: [2865 - 2871]
Pages: 7
DOI: 10.2174/092986707782359981
Price: $58

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