Abstract
Mass spectrometric imaging (MSI) integrates multiple fields of analytical and biomedical research with the goal of generating chemical maps that present the identity and location of the elements, molecules, and molecular complexes that comprise biological structures. Rapid advances in the development of MSI, which include a broad range of sampling and mass spectrometry strategies, allow the increasingly information-rich creation of chemical images of structurally complex tissues, individual cells, and even single chromosomes. Here we describe a variety of MSI techniques available to investigate the nervous system, with particular focus on the capability of MSI to examine both normal and diseased brain function. An important investigative tool, MSI offers tremendous potential in fundamental studies of brain chemistry, localization of pharmaceutical compounds, and the discovery of biomarkers for different neuropathologies.
Keywords: Mass spectrometric imaging, MALDI MSI, Biomarker discovery, SIMS
Current Pharmaceutical Design
Title: Mass Spectrometric Imaging of the Nervous System
Volume: 13 Issue: 32
Author(s): S. S. Rubakhin, N. G. Hatcher, E. B. Monroe, M. L. Heien and J. V. Sweedler
Affiliation:
Keywords: Mass spectrometric imaging, MALDI MSI, Biomarker discovery, SIMS
Abstract: Mass spectrometric imaging (MSI) integrates multiple fields of analytical and biomedical research with the goal of generating chemical maps that present the identity and location of the elements, molecules, and molecular complexes that comprise biological structures. Rapid advances in the development of MSI, which include a broad range of sampling and mass spectrometry strategies, allow the increasingly information-rich creation of chemical images of structurally complex tissues, individual cells, and even single chromosomes. Here we describe a variety of MSI techniques available to investigate the nervous system, with particular focus on the capability of MSI to examine both normal and diseased brain function. An important investigative tool, MSI offers tremendous potential in fundamental studies of brain chemistry, localization of pharmaceutical compounds, and the discovery of biomarkers for different neuropathologies.
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Cite this article as:
Rubakhin S. S., Hatcher G. N., Monroe B. E., Heien L. M. and Sweedler V. J., Mass Spectrometric Imaging of the Nervous System, Current Pharmaceutical Design 2007; 13 (32) . https://dx.doi.org/10.2174/138161207782360708
DOI https://dx.doi.org/10.2174/138161207782360708 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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