The ATP-Binding Cassette Transporter Subfamily A Member 1 (ABC-A1) and Type 2 Diabetes: An Association Beyond HDL Cholesterol

Author(s): Carlos A. Aguilar Salinas, Ivette Cruz-Bautista, Roopa Mehta, Ma T. Villarreal-Molina, Francisco J. G. Perez, Ma T. Tusie-Luna, Samuel Canizales-Quinteros.

Journal Name: Current Diabetes Reviews

Volume 3 , Issue 4 , 2007

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Abstract:

Recent findings from several groups demonstrate that ABC-A1 participates in the pathogenesis of the metabolic syndrome and type 2 diabetes. A variant of the ABC-A1 gene (R230C) is associated with the metabolic syndrome and its co-morbidities in Mexicans. Its presence is associated with an increased risk for obesity, the metabolic syndrome and type 2 diabetes. R230C is found exclusively in Amerindian and Amerindian-derived populations. Moreover, animal models confirm the participation of ABC-A1 in the pathogenesis of diabetes. Mice lacking AbcA1 specifically in beta cells had glucose intolerance at 8 weeks of age. The absence of ABC-A1 led to cholesterol accumulation within the beta cell plasma membrane, suggesting that cholesterol may play a role in the insulin secretory pathway. In conclusion, ABC-A1 may be more than a determinant of HDL-cholesterol. It may provide a link between components of the metabolic syndrome and atherosclerosis.

Keywords: ABC A1, Metabolic syndrome, Mexico, Abdominal obesity, LXR

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Article Details

VOLUME: 3
ISSUE: 4
Year: 2007
Page: [264 - 267]
Pages: 4
DOI: 10.2174/157339907782329979
Price: $65

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