Role of Focal Adhesion Kinase in Human Cancer: A Potential Target for Drug Discovery

Author(s): Edward Kyu-Ho Han, Thomas McGonigal.

Journal Name: Anti-Cancer Agents in Medicinal Chemistry

Volume 7 , Issue 6 , 2007

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Abstract:

The focal adhesion kinase (FAK) is a non-receptor tyrosine kinase that localizes to the points of cell contact with the extracellular matrix, called focal adhesions. FAK is involved in several cellular processes including invasion, motility, proliferation and apoptosis. In in vivo animal studies, FAK has been shown to contribute to tumor development and malignancy. Furthermore, FAK expression was shown to be elevated in a number of human cancers. Increased FAK expression and activity are correlated with malignant phenotype and poor prognosis in patients. Taken together, these studies suggest that FAK is a potentially good target for drug discovery. In this review, FAK and its relationship to cancer, as well as approaches to therapeutic intervention of FAK will be discussed.

Keywords: Focal adhesion kinase (FAK), tumor, siRNA, small molecule inhibitors, FAK expression

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Article Details

VOLUME: 7
ISSUE: 6
Year: 2007
Page: [681 - 684]
Pages: 4
DOI: 10.2174/187152007784111296
Price: $58

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