Cardiovascular & Hematological Agents in Medicinal Chemistry

(Formerly Current Medicinal Chemistry - Cardiovascular & Hematological Agents)

Debabrata Mukherjee
Department of Internal Medicine
Texas Tech University
El Paso,TX
USA

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Preclinical Testing of Drug-Induced Proarrhythmia: Value of Transgenic Models

Author(s): L. Fabritz, G. Breithardt, P. Kirchhof.

Abstract:

Drug-induced proarrhythmia is a serious medical problem that causes relevant morbidity and mortality. It is also a relevant problem for the development of novel pharmacological compounds. Therefore, there is a need for sensitive, specific and high-throughput preclinical tests to detect a risk for drug-induced proarrhythmia early in the development of new drugs. The review focuses on the potential role of transgenic models with altered repolarisation but without overt structural heart disease for drug-induced proarrhythmia screening. Today, selected murine models with alterations in K+, Na+ channels and ankyrin are available. In the future, transgenic rabbit and Zebra fish models may also be used.

Keywords: Drug-induced proarrhythmia, repolarisation, long QT syndrome, action potential prolongation, torsades de pointes, transgenic model, experimental model, ion channels

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Article Details

VOLUME: 5
ISSUE: 4
Year: 2007
Page: [289 - 294]
Pages: 6
DOI: 10.2174/187152507782109881
Price: $58