ISSN (Print): 1871-529X
ISSN (Online): 2212-4063
Volume 18, 3 Issues, 2018
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ISSN (Print): 1871-529X
ISSN (Online): 2212-4063
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Garry X. Shen University of Manitoba Winnipeg, MB Canada
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10 Abstract Ahead of Print are available electronically
17 Ahead of Print article(s) are available electronically
The prevalence of cardiovascular and metabolic disease in China has been rapidly increased during last 20 years in parallel
with the rapid industrialization of the country [1, 2]. Hypertension, obesity, unhealthy diet and inactivity lifestyle appear to play
important roles in the boost of heart disease, stroke and diabetes in China [3, 4]. Heart disease is the number 2 cause of death in
Canada . One out 3 of Canadians is diagnosed as diabetes or pre-diabetes . Since 2011, Chinese Atherosclerosis Society
(CAS) and Canadian Society of Atherosclerosis , Thrombosis and Vascular Biology (CSATVB) have organized 5 joint
symposiums which were held in Beijing (2011), Vancouver (2013), Nanjing (2014), Calgary (2016) and Hengyang (2017).
More than 1,000 of researchers, clinicians and trainees from China and Canada presented their research results. The CASCSATVB
joint symposiums become an important platform to develop scientific collaborations between institutes and
researchers in the two countries. The Cardiovascular and Hematologic Disorders-Drug Target journal published two hot topic
issues as the proceeding of those joint symposiums [7, 8]. This special issue selected 4 mini-reviews presented by Canadian or
Chinese researchers and their colleagues on recent joint symposiums.
Dr. Michael Walsh in University of Calgary reported in his plenary lecture on the regulation of smooth muscle myosin light
chain phosphatase by multi-site phosphorylation of the myosin targeting subunit, Myosin phosphatase targeting subunit 1
(MYPT1). Their findings provided deep insight for the phoshphorylation of MYPT1, which may be important therapeutic target
for a number of cardiovascular disorders including chronic heart failure, intestinal inflammation, pulmonary hypertension,
asthma or diabetic vasculopathy .
Dr. Lemin Zheng and his colleagues in Beijing University School of Medicine reported their findings of the involvement of
Connexin 43 and myocardial ischemia-reperfusion injury . Connexin 43 is the major component of cardiomyocyte Gap
Junctions and plays an important role in cardioprotection. Myocardial connexin 43 is upregulated in acute myocardial ischemic
injury and it becomes an emerging therapeutic target for ischemic/perfusion injury of heart.
Dr. Paolo Raggi and his colleague in University of Alberta reported the findings of his group on role of epicardial adipose
tissue in atherosclerosis. Their studies suggest that adipose tissue is an important source for inflammatory mediators, which
play critical roles in the initiation of inflammation on endothelial surface and atherogenesis .
Dr. Huiyong Yin and his colleagues in Shanghai Institute of Life Sciences demonstrated their research progress in the field
of Cholesterol Homeostasis and Liver X Receptor (LXR) in Atherosclerosis. The activation of LXR in liver inhibits cholesterol
uptake and enhances cholesterol efflux. LXR has become a therapeutic target for the treatment of atherosclerosis. Natural LXR
agonists are mostly oxysterol or cytochrome P450. Synthesized LXR agonists have been developed (T0901317 and GW3965).
In contrast, polyunsaturated fatty acids and geranylgeranylpyrophosphate inhibited LXR activity .
Since the reviews have been written between 2016 and 2017, many related studies have been done by now. The studies
described in the thematic issue reflect the rapid progresses in atherosclerosis researches among researchers in Canada and
China. Multiple researchers reported the findings generated from the collaborative studies between the two countries resulted
from previous joint symposiums of CSATVB and CAS. We are looking forward to see more of collaborative researches to be
developed between the researchers and trainees between the two countries and societies.