Preparation and Property Screening of the Solid Inclusion Complex of Norfloxacin with p-Sulfonated Calix[4]arene

Author(s): Qin Lu , Yunyou Zhou , Junyong Sun , Lian Wu , Huapeng Yu , Hongwei Xu , Lun Wang .

Journal Name: Combinatorial Chemistry & High Throughput Screening

Volume 10 , Issue 6 , 2007

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The complexation of norfloxacin (NFLX) by p-sulfonated calix[4]arene (SC4A) in aqueous solution has been studied by fluorescence spectroscopy and 1H NMR spectroscopy. A 1:1 stoichiometry and a 8086 L mol-1 stability constant of the NFLX-SC4A complex was obtained by spectrofluorometric titrations. The equimolar solid state inclusion complex of NFLX-SC4A was prepared by the co-precipitation method and then characterized by various techniques, including differential scanning calorimetry (DSC), X-ray powder diffractometry (XRD), Fourier-transform infrared analysis (FT-IR) and scanning electron microscopy (SEM). The experimental results of these chemical property screenings confirmed that NFLX and SC4A can form a stable host-guest complex in the solid state, and SC4A appears to function as a complexing and solubilizing agent for NFLX.

Keywords: p-Sulfonated calix[4]arene, norfloxacin, solid inclusion complex

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Article Details

Year: 2007
Page: [480 - 485]
Pages: 6
DOI: 10.2174/138620707781996448
Price: $58

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