Abstract
With the alarming increase in the incidence of diabetes mellitus worldwide, there is a growing need to develop new strategies to control hyperglycemia. Currently available treatments cause various adverse effects and do not necessarily achieve optimal glycemic control. Recently, peptides that may ameliorate the symptoms of diabetes mellitus have been investigated extensively and show great promise. Synthetic analogs of amylin and incretin mimetics may be ideal adjuncts to diabetes therapy. Amylin analogs significantly improve postprandial control in patients with either type 1 or type 2 diabetes without an increased risk of hypoglycemia or weight gain. Incretin mimetics are a new option for patients suffering from type 2 diabetes and are being considered as a stand-alone therapy. The present paper reviews novel peptides as potential agents for glucose control and prevention of the complications associated with diabetes.
Keywords: Diabetes mellitus, peptides, alternatives
Current Drug Therapy
Title: Novel Peptides: An Alternative Approach for the Treatment of Diabetes Mellitus
Volume: 2 Issue: 3
Author(s): Rumi Ghosh, Vaidehi Thanawala and Vilasrao J. Kadam
Affiliation:
Keywords: Diabetes mellitus, peptides, alternatives
Abstract: With the alarming increase in the incidence of diabetes mellitus worldwide, there is a growing need to develop new strategies to control hyperglycemia. Currently available treatments cause various adverse effects and do not necessarily achieve optimal glycemic control. Recently, peptides that may ameliorate the symptoms of diabetes mellitus have been investigated extensively and show great promise. Synthetic analogs of amylin and incretin mimetics may be ideal adjuncts to diabetes therapy. Amylin analogs significantly improve postprandial control in patients with either type 1 or type 2 diabetes without an increased risk of hypoglycemia or weight gain. Incretin mimetics are a new option for patients suffering from type 2 diabetes and are being considered as a stand-alone therapy. The present paper reviews novel peptides as potential agents for glucose control and prevention of the complications associated with diabetes.
Export Options
About this article
Cite this article as:
Ghosh Rumi, Thanawala Vaidehi and Kadam J. Vilasrao, Novel Peptides: An Alternative Approach for the Treatment of Diabetes Mellitus, Current Drug Therapy 2007; 2 (3) . https://dx.doi.org/10.2174/157488507781695658
DOI https://dx.doi.org/10.2174/157488507781695658 |
Print ISSN 1574-8855 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3903 |
Call for Papers in Thematic Issues
Novel Therapeutic Approaches and Biomarkers for Chronic Kidney Disease (CKD)
The thematic issue on "Novel Therapeutic Approaches and Biomarkers for CKD" aims to provide a comprehensive exploration of cutting-edge strategies for the management of chronic kidney disease (CKD). This issue will delve into emerging therapeutic targets, focusing on critical aspects such as podocyte injury, endothelial dysfunction, and tubulointerstitial fibrosis, which ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Sexual Dimorphism in Autoimmune Disease
Current Molecular Medicine Endophthalmitis
Anti-Infective Agents in Medicinal Chemistry Caffeine and Glucose Metabolism at Rest Period, During, and Post Exercise in Diabetes Mellitus: A Systematic Review
Current Nutrition & Food Science New Insulin-Mimetic and Hypoglycemic Hetero-Binuclear Zinc(II)/ Oxovanadium(IV) Complex
Current Inorganic Chemistry (Discontinued) The Challenges in Moving from Ageing to Successful Longevity
Current Vascular Pharmacology A Healthy Gut for a Healthy Brain: Preclinical, Clinical and Regulatory Aspects
Current Neuropharmacology Opportunistic Pathogens in Diabetic Foot Lesions
Current Diabetes Reviews Anthocyanins as a Potential Therapy for Diabetic Retinopathy
Current Medicinal Chemistry Diuretic-Associated Electrolyte Disorders in the Elderly: Risk Factors, Impact, Management and Prevention
Current Drug Safety Peroxisome Proliferator-Activated Receptor (PPAR)β /δ: A New Potential Therapeutic Target for the Treatment of Metabolic Syndrome
Current Molecular Pharmacology The Multiple Roles of Vitamin D in Human Health. A Mini-Review
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) Editorial: Cardiovascular Disease Mortality Rates are Plateauing in Certain Age Groups and Regions. Can we Keep them Declining?
Current Vascular Pharmacology Leptin Signaling in Blood Platelets as a Target for Therapeutic Intervention
Current Signal Transduction Therapy Endothelial Dysfunction in Diabetes: From Mechanisms to Therapeutic Targets
Current Medicinal Chemistry Effect of Simvastatin use on Autonomic Function in Patients with End Stage Renal Disease
Cardiovascular & Hematological Disorders-Drug Targets COVID-19: A Great Mime or a Trigger Event of Autoimmune Manifestations?
Current Rheumatology Reviews Chronic Exposure to Low-Level Cadmium in Diabetes: Role of Oxidative Stress and Comparison with Polychlorinated Biphenyls
Current Drug Targets DNA Damage and Epigenetic Changes in Kidney Diseases - Focused on Transcription Factors in Podocytes
Current Hypertension Reviews Immunomodulatory Activity of Mesenchymal Stem Cells
Current Stem Cell Research & Therapy Criteria for Creating and Assessing Mouse Models of Diabetic Neuropathy
Current Drug Targets