New Pyrroles with Potential Antimycobacterial, Antifungal and Selective COX-2 Inhibiting Activities. Synthetic Methodologies

Author(s): M. Biava, G. C. Porretta, G. Poce, S. Supino, G. Sleiter.

Journal Name: Current Organic Chemistry

Volume 11 , Issue 12 , 2007

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Abstract:

Tuberculosis (TB) and fungal diseases are opportunistic infections that very often complicate the immunological response in HIV-infected individuals [1-3]. During our studies on novel antimycobacterial and antifungal agents we synthesized a number of new pyrrole derivatives and among them some proved very active against both fungi and mycobacteria. Some others instead were very selective against mycobacteria only. So we pursued a program aimed at individuating the chemical groups or their association, responsible for the particular activity. Moreover, many other pyrroles we synthesized showed to be very active as COX-2 selective inhibitors. In this review we describe our approaches to the synthesis of the pyrrolic structures studied.

Keywords: Pyrrolnitrin, Candida albicans, electrophilic attack, delocalization, mycobacteria

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Article Details

VOLUME: 11
ISSUE: 12
Year: 2007
Page: [1092 - 1112]
Pages: 21
DOI: 10.2174/138527207781369272
Price: $58