Abstract
A tremendous interest exists in the Western world in Traditional Chinese Medicine (TCM) with rapidly increasing export rates of TCM products from China to Europe and USA. This led to a national decision of the Chinese government to implement a “Plan for the Modernization of Chinese Medicine”. Concerning the use of Chinese medicinal herbs, two major directions can be distinguished. One field is phytochemistry and pharmacognosy. Secondary metabolites isolated from Chinese plants can be easily subjected to pharmacological, molecular biological, and pharmacogenomic analyses using methods of modern cell and molecular biology as exemplified for camptothecin from Camptotheca acuminata in the present review. The second field of interest is phytomedicine. Standardized international quality guidelines help to improve quality, safety and efficacy of Chinese medicinal herbs. Sustainability of natural products from TCM can be reached by breeding high-yield varieties or by biotechnological approaches. In the long term, natural products from TCM can contribute to the development of molecular target-guided therapies and individualized treatment strategies.
Keywords: Phytochemistry, pharmacognosy, phytomedicine, biotechnology, pharmacogenomics
Current Medicinal Chemistry
Title: Molecular Target-Guided Tumor Therapy with Natural Products Derived from Traditional Chinese Medicine
Volume: 14 Issue: 19
Author(s): Thomas Efferth, Yu-jie Fu, Yuan-gang Zu, Gunter Schwarz, Venkata Sai Badireenath Konkimalla and Michael Wink
Affiliation:
Keywords: Phytochemistry, pharmacognosy, phytomedicine, biotechnology, pharmacogenomics
Abstract: A tremendous interest exists in the Western world in Traditional Chinese Medicine (TCM) with rapidly increasing export rates of TCM products from China to Europe and USA. This led to a national decision of the Chinese government to implement a “Plan for the Modernization of Chinese Medicine”. Concerning the use of Chinese medicinal herbs, two major directions can be distinguished. One field is phytochemistry and pharmacognosy. Secondary metabolites isolated from Chinese plants can be easily subjected to pharmacological, molecular biological, and pharmacogenomic analyses using methods of modern cell and molecular biology as exemplified for camptothecin from Camptotheca acuminata in the present review. The second field of interest is phytomedicine. Standardized international quality guidelines help to improve quality, safety and efficacy of Chinese medicinal herbs. Sustainability of natural products from TCM can be reached by breeding high-yield varieties or by biotechnological approaches. In the long term, natural products from TCM can contribute to the development of molecular target-guided therapies and individualized treatment strategies.
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Cite this article as:
Thomas Efferth , Yu-jie Fu , Yuan-gang Zu , Gunter Schwarz , Venkata Sai Badireenath Konkimalla and Michael Wink , Molecular Target-Guided Tumor Therapy with Natural Products Derived from Traditional Chinese Medicine, Current Medicinal Chemistry 2007; 14 (19) . https://dx.doi.org/10.2174/092986707781368441
DOI https://dx.doi.org/10.2174/092986707781368441 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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