Current Drug Targets

Francis J. Castellino
Kleiderer-Pezold Professor of Biochemistry
Director, W.M. Keck Center for Transgene Research
Dean Emeritus, College of Science
230 Raclin-Carmichael Hall, University of Notre Dame
Notre Dame, IN 46556


Statins Exert Multiple Beneficial Effects on Patients Undergoing Percutaneous Revascularization Procedures

Author(s): Kosmas I. Paraskevas, Vasilios G. Athyros, Despina D. Briana, Anna I. Kakafika, Asterios Karagiannis and Dimitri P. Mikhailidis

Affiliation: Department of Clinical Biochemistry (Vascular Prevention Clinic), Royal Free Hospital and Royal Free University College Medical School, Pond Street, London NW3 2QG, UK.


Background and aims: Statins are an essential component of the therapeutic approach of patients with atherosclerotic disease. Statin use is also associated with improved peri-operative and long-term outcomes in these patients. We aimed to define the role of statin treatment in patients undergoing percutaneous revascularization procedures. Literature search method: We searched Medline for studies assessing the effect of statin treatment on percutaneous interventions. Literature search results: Early statin treatment is associated with improved outcomes in patients undergoing percutaneous coronary intervention procedures. Current evidence implies that statin treatment may also play a beneficial role in the management of patients undergoing percutaneous renal artery revascularization and endovascular abdominal aortic aneurysm repair, carotid angioplasty/stenting and endovascular peripheral arterial interventions. Conclusions: Preliminary data suggest that statins exert multiple beneficial actions in patients undergoing percutaneous interventions. Future randomized trials are expected to further evaluate the beneficial effects of statins in these procedures.

Keywords: Statins, percutaneous coronary intervention, peripheral arterial disease, endovascular abdominal aortic aneurysm repair, carotid angioplasty, carotid stenting

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Article Details

Page: [942 - 951]
Pages: 10
DOI: 10.2174/138945007781386893
Price: $58