Abstract
Macroautophagy (hereafter referred as to autophagy) is a vacuolar lysosomal degradative pathway for cytoplasmic macromolecules and organelles. There is growing evidence that autophagy is controlled by tumor-regulating molecules, and that it is downregulated during the early stages of tumorigenesis. Nevertheless, the relationship between autophagy and tumor progression seems to be complex, since in response to various stress situations, cancer cells are able to trigger autophagy either as a survival mechanism or conversely as a mechanism leading to cell death. Therefore, depending on the context, autophagy may trigger opposite outcomes in cancer cell fate. These two aspects of autophagy should be further taken into account in view of its possible modulation for cancer treatment.
Keywords: Autophagy, tumor, cancer therapy, apoptosis, cell death, cell survival
Current Cancer Therapy Reviews
Title: Macroautophagy as a Target of Cancer Therapy
Volume: 3 Issue: 3
Author(s): Severine Lorin, Patrice Codogno and Mojgan Djavaheri-Mergny
Affiliation:
Keywords: Autophagy, tumor, cancer therapy, apoptosis, cell death, cell survival
Abstract: Macroautophagy (hereafter referred as to autophagy) is a vacuolar lysosomal degradative pathway for cytoplasmic macromolecules and organelles. There is growing evidence that autophagy is controlled by tumor-regulating molecules, and that it is downregulated during the early stages of tumorigenesis. Nevertheless, the relationship between autophagy and tumor progression seems to be complex, since in response to various stress situations, cancer cells are able to trigger autophagy either as a survival mechanism or conversely as a mechanism leading to cell death. Therefore, depending on the context, autophagy may trigger opposite outcomes in cancer cell fate. These two aspects of autophagy should be further taken into account in view of its possible modulation for cancer treatment.
Export Options
About this article
Cite this article as:
Severine Lorin , Patrice Codogno and Mojgan Djavaheri-Mergny , Macroautophagy as a Target of Cancer Therapy, Current Cancer Therapy Reviews 2007; 3 (3) . https://dx.doi.org/10.2174/157339407781368369
DOI https://dx.doi.org/10.2174/157339407781368369 |
Print ISSN 1573-3947 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6301 |
Call for Papers in Thematic Issues
Current progress in Protein Degradation and Cancer Therapy
argeted Protein Degradation is gaining momentum in cancer therapy, it facilitate targeting undruggable proteins, it overcome cancer resistance and avoid undesirable side effects. Thus small molecules degraders have emerged as novel therapeutic strategy. Targeted protein degradation (TPD), the process of eliminating a protein of interest hold a great promise for ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Nanomedical Applications of Amphiphilic Dendrimeric Micelles
Current Medicinal Chemistry SAR, QSAR and Docking of Anticancer Flavonoids and Variants: A Review
Current Topics in Medicinal Chemistry Prevention of Colitis-associated Cancer: Natural Compounds that Target the IL-6 Soluble Receptor
Anti-Cancer Agents in Medicinal Chemistry Jatropha curcas: From Biodiesel Generation to Medicinal Applications
Recent Patents on Biotechnology The Role of Amitriptyline in the Management of Non-small Cell Lung Cancer
Current Cancer Therapy Reviews p16<sup>INK4</sup> as a Biomarker in Oropharyngeal Squamous Cell Carcinoma
Recent Patents on Biomarkers Current Protein-based Anti-angiogenic Therapeutics
Mini-Reviews in Medicinal Chemistry miR-15b Suppression of Bcl-2 Contributes to Cerebral Ischemic Injury and is Reversed by Sevoflurane Preconditioning
CNS & Neurological Disorders - Drug Targets Insights on the Neuromodulatory Propensity of Selaginella (Sanjeevani) and its Potential Pharmacological Applications
CNS & Neurological Disorders - Drug Targets An Update on the Other Telomerase Inhibitors: Non-G-Quadruplex Interactive Agent, Non-Antisense, Non-Reverse Transcriptase Telomerase Inhibitors
Medicinal Chemistry Reviews - Online (Discontinued) SCYL1-BP1 Affects Cell Cycle Arrest in Human Hepatocellular Carcinoma Cells via Cyclin F and RRM2
Anti-Cancer Agents in Medicinal Chemistry Biomarkers for Cancers in Women: Present Status and Future Perspectives
Current Women`s Health Reviews Synthesis and Evaluation of <sup>198</sup>Au/PAMAM-MPEG-FA against Cancer Cells
Anti-Cancer Agents in Medicinal Chemistry Himalayan Plants as a Source of Anti-Cancer Agents: A Review
The Natural Products Journal Harnessing the Power of Cerenkov Luminescence Imaging for Gastroenterology: Cerenkov Luminescence Endoscopy
Current Medical Imaging Dantrolene Potentiates the Antineoplastic Effect of Sorafenib in Hepatocellular Carcinoma via Targeting Ca<sup>+2</sup>/PI3K Signaling Pathway
Current Molecular Pharmacology Recent Advances in Medicinal Applications of Coinage-Metal (Cu and Ag) N-Heterocyclic Carbene Complexes
Current Topics in Medicinal Chemistry Current Advances in Anti-Influenza Therapy
Current Medicinal Chemistry Restoration of Chemoresistance Mechanism by Novel Drug Therapies in Breast Cancer Cell Lines
Current Drug Therapy Role of the Renin-Angiotensin System in Gynecologic Cancers
Current Cancer Drug Targets