Current Cancer Therapy Reviews

Kurt S. Zaenker
Institute of Immunology and Experimental Oncology University Witten/Herdecke
Stockumerstraße 10, 58448 Witten
Germany

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Fluoroquinolones Prophylaxis of Bacterial Infections in Neutropenic Patients: Time to Re-Evaluate

Author(s): Mario Cruciani.

Abstract:

Fluoroquinolones have been studied extensively as prophylaxis in neutropenic cancer patients. There is a large body of evidence suggesting that fluoroquinolones are a valuable choice for preventing bacterial infections in neutropenic cancer patient. As yet, there is no question that prophylaxis with fluoroquinolones has led to a decrease in the occurrence of gram-negative infections in neutropenic patients. By contrast, the benefits of fluoroquinolone prophylaxis on other parameters of infection-related morbidity and on the occurrence of infection-related mortality are not clear. Moreover, the use of fluoroquinolones is not without risk. Reports of fluoroquinolone-resistant Escherichia coli causing bacteremia among cancer patients are matter of concern. Recent well conducted, large clinical trials confirm the long lasting interest in the use of fluoroquinolones prophylaxis. Moreover, a reduction in mortality has been demonstrated in recent metaanalyses, though the generalizability of this finding is uncertain. Reports from cancer centers in Europe have shown a rebound of gram-negative bacteremias after discontinuation in the use of prophylaxis with fluoroquinolones. In light of the these findings, prophylaxis with a quinolone during granulocytopenia, where resistance permits, is still appropriate.

Keywords: Granulocytopenia, antibiotic prophylaxis, quinolones, cancer

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Article Details

VOLUME: 3
ISSUE: 3
Year: 2007
Page: [164 - 173]
Pages: 10
DOI: 10.2174/157339407781368314
Price: $58