Chemical and Pharmacological Significance of 1,4-Dihydropyridines

Author(s): Ghanta Mahesh Reddy, Mehendra Shiradkar, Akula Kalyan Chakravarthy.

Journal Name: Current Organic Chemistry

Volume 11 , Issue 10 , 2007

Abstract:

1,4-Dihydropyridines are excellent precursors of various pharmacologically important molecules which possess calcium channel blocking activity. The synthesis of various 1,4-dihydro pyridines and their importance is reviewed for the first time to our knowledge.

Keywords: electron-withdrawing groups, 4-unsubstituted pyridine, calcium antagonists, vasodilation, hypertension

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Article Details

VOLUME: 11
ISSUE: 10
Year: 2007
Page: [847 - 852]
Pages: 6
DOI: 10.2174/138527207781024058
Price: $58

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